オリザ油化株式会社

研究开发

论文

A行


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产品名称 红姜提取物
发表年份 2010
杂志 Journal of Medicinal Food
标题 Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents.
作者 Shimoda H., Shan S. J., Tanaka J., Seki A., Seo J. W., Kasajima N., Kasajima N., Tamura S., Ke Y., Murakami N.
摘要 红姜提取物可促进抑制巨噬细胞向炎症部位迁移、抑制COX-2所引起的PG产生以及NO的产生,有望缓解以类风湿为代表的关节病。


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产品名称 红米提取物
发表年份 2020
杂志 Journal of Rice Research
标题 Identification of Chemical Structures of Hypolipidemic Proanthocyanidins in Red Rice Enhancing Acyl CoA Oxidase Expression.
作者 Tamura S., Yan K., Kawano T., Ohnishi-Kameyama M., Tanaka J., Shimoda H., Murakami N.
摘要 红米中所含有的原花青素,有望具有提高脂质代谢酶基因表达的效果,从而有助于预防脂肪肝和高血脂。


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产品名称 布里奇果提取物
发表年份 2020
杂志 Function Foods in Health and Disease
标题 Moriche Palm (Aguaje) Extractimproves indefinite complaintsin Japanese females: arandomized,placebo-controlled,double-blind trial.
作者 Takara T., Yamamoto K., Suzuki N., Yamashita S., Iio S., Noguchi H., Kakinuma T., Baba. Yamamoto S., Morikawa T., Takeda S., Shimoda H.
摘要 以健康的日本女性为对象,连续8周摄取布里奇果提取物后,月经前的烦躁情绪、月经中的疼痛、水分积存、集中力等问题都有显著改善。由此可见,布里奇果萃取液有望预防女性月经前后的疼痛和不定愁诉。

产品名称 布里奇果提取物
发表年份 2021
杂志 Journal of Food Biochemistry
标题 Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of Mauritia Flexuosa (Moriche Palm)
作者 Miyasaka K., Takeda S., Nakamura S., Matsuda H., Shimoda H.
摘要 由于确认了在布里奇果提取物中所含有的甲氧基黄烷具有雌激素样作用和抗雄激素样作用,因此布里奇果提取物有望具有调节激素的作用。


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产品名称 α-硫辛酸
发表年份 2007
杂志 食品卫生学杂志
标题 α-硫辛酸制造工序中所生成聚合物的安全性和结构分析
作者 下田博司、田中润司、关AZUSA、本田晴哉、赤荻诚一郎、小松原博文、铃木信夫、龟山真由美、田村理、村上启寿
摘要 摄取混有1%α-脂酸合成过程中所产生胶状聚合物的α-脂酸,对健康的影响程度较小。


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产品名称 草莓籽提取物
发表年份 2018
杂志 PLoS One
标题 Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents.
作者 Takeda S., Shimoda H., Takarada T., Imokawa G.
摘要 草莓籽提取物及其所含成分噻虫胺,可能通过促进神经酰胺合成相关酶基因的表达来预防皮肤干燥。

产品名称 草莓籽提取物
发表年份 2019
杂志 Journal of Biomedical Sciences
标题 Tiliroside, a constituent of strawberry seeds, slightly enhances hyaluronan production via hyaluronan synthase 2 expression in mouse skin and human fibroblasts.
作者 Shimoda H., Tanaka J., Zaiki K., Nakaoji K.
摘要 草莓籽提取物中所含的噻虫胺可能通过促进透明质酸合成酶基因的表达来预防皮肤干燥。


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产品名称 温州蜜柑提取物
发表年份 2012
杂志 Journal of Pharmacy and Pharmacology
标题 Cryptoxantin suppressed UVB-induced melanogenesis in mouse: involvement of the inhibition of prostaglandin E2 and melanocyte-stimulating hormone pathway.
作者 Shimoda H., Shan S.H., Tanaka J., Maoka T.
摘要 温州蜜柑提取物中的β-隐黄素可能通过抑制黑素生成因子和角质形成因子的表达,实现预防皮肤色素沉着。


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产品名称 米萃取γ-氨基丁酸™提取物
发表年份 2001
杂志 日本食品工学学会杂志
标题 有机溶剂脱脂对大米胚芽中4-氨基丁酸(GABA)积累的影响
作者 三枝贵代、冈田忠司、村井弘道、森隆、堀野俊郎、大森正司、伊藤昌博、小野田明彦
摘要 大米胚芽中蓄积大量GABA,其理想精制条件为,优选在不含乙醇的条件下,30℃以上的正己烷脱脂、通过加水蓄积GABA,并在30~50℃的温度下进行干燥和加热处理。


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产品名称 米神经酰胺™
发表年份 2009
杂志 细胞
标题 源自大米的神经鞘氨醇糖脂的作用
作者 下田博司
摘要 以皮肤干燥且有皮肤粗糙倾向者为对象,开展为期6周的ORYZA Ceramide摄取后,皮肤的水分量、光滑度、鳞屑及纹理都得到了改善,由此可证明ORYZA ceramide是一种能让皮肤保持健康的食品原料。

产品名称 米神经酰胺™
发表年份 2012
杂志 Journal of Medicinal Food
标题 Changes in ceramides and glucosylceramides in mouse skin and human epidermal equivalents by rice-derived glucosylceramide.
作者 Shimoda H., TerazawaS., Hitoe S., Tanaka J., Nakamura S., Matsuda H., Yoshikawa M.
摘要 可认为“ORYZA seramide®”中所含有的来自于大米的葡萄糖基神经酰胺,可促进与神经酰胺合成相关的酶基因的表达,从而实现补充角质层的保湿和屏障功能的作用。

产品名称 米神经酰胺™
发表年份 2021
杂志 PLoS One
标题 β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model
作者 Takeda S., Shimoda H., Imokawa G.
摘要 可认为,ORYZA seramide®中所含的β-半胱氨酸葡糖苷可通过促进神经酰胺合成相关酶基因的表达,从而实现补充角质层的保湿和屏障功能的作用。

产品名称 米神经酰胺™
发表年份 2021
杂志 Functional Foods in Health and Disease
标题 Oryza Ceramide®, a rice-derived extract consisting of glucosylceramides and β-sitosterol glucoside, improves facial skin dehydration in Japanese subjects.
作者 Takara T., Yamamoto K., Suzuki N., Yamashita S., Iio S., Noguchi H., Kakinuma T., Baba A., Takeda S., Yamada W., Sarita Shrestha., Yoshiaki Manse., Toshio Morikawa., Shimoda H.
摘要 以健康日本的女性为对象,在连续12周摄取ORYZA ceramide®(大米神经酰胺)后,确认其脸部的水分蒸散量(TEWL)、嘴唇的水分量、毛孔的大小均得到改善。由此可见,通过摄取orizeramide®,有望预防皮肤干燥。


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产品名称 米胜肽™
发表年份 2018
杂志 Journal of Functional Foods
标题 Isolation of activating factors of serotonin N-acetyltransferase from rice peptides.
作者 Moritani C., Kawakami K., Fujita A., Kawakami L., Shimoda H., Hatanaka T., Tsuboi S.
摘要 文中提出ORYZA Peptide®(米胜肽™ )可通过激活褪黑激素合成相关酶,具有使人更容易入睡的效果。

产品名称 米胜肽™
发表年份 2019
杂志 Journal of Rice Research
标题 Effect of Rice Peptide Beverage Combined with Light Walking Exercise on Body Fat Parameters in Japanese Subjects.
作者 Oike Y., Miyanaga T., Hori Y., Takahashi A., Kikuchi M., Shimoda H.
摘要 以健康女性为对象进行为期8周的ORYZA Peptide®(米胜肽™ )摄取和轻度步行,未发现脂肪减少。但是高剂量的摄入则可能会导致脂肪减少。

产品名称 米胜肽™
发表年份 2020
杂志 ACS Omega
标题 Protective effects of rice peptide Oryza Peptide-P60 against oxidative injury through activation of Nrf2 signaling pathway in vitro and in vivo.
作者 Moritani C., Kawakami K., Shimoda H., Hatanaka T., Suzaki E., Tsuboi S.
摘要 ORYZA Peptide®(米胜肽™ )可能通过激活Nrf2途径来诱导谷胱甘米胜肽™ 合成和抗氧化活性,从而预防氧化应激所引发的疾病。

KA行


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产品名称 管花肉苁蓉提取物
发表年份 2009
杂志 American Journal of Chinese Medicine
标题 The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional clued medicine, in mice.
作者 Shimoda H., Tanaka J., Takahara Y., Takemoto K., Shan S.J., Su M.H.
摘要 可认为柑橘提取物能促进与胆固醇输送及代谢相关的基因表达,从而对减肥有效。


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产品名称 谷维素
发表年份 1982
杂志 日本食品工学学会杂志
标题 阿魏酸酯的抗氧化性及其与氨基化合物协同性的研究
作者 岡田忠司、中川紀代司、山口直彦
摘要 发现γ-Oryzanol(谷维素)中所含有的阿魏酸酯单独使用对亚油酸和猪油的抗氧化性较低,而与甘氨酸并用则可得到改善。

产品名称 谷维素
发表年份 1983
杂志 油化学
标题 谷维素的抗氧化性和药理作用
作者 冈田忠司、山口直彦
摘要 γ-Oryzanol(谷维素)具有耐热性和抗氧化活性,还具有生长促进作用、间脑功能调节作用等效果,因此有望作为食品的抗氧化物质应用和作为医药品得以应用。

产品名称 谷维素
发表年份 2017
杂志 Toxicology Reports
标题 Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats.
作者 Moon S.H., Kim D., Shimizu N., Okada T., Hitoe S., Shimoda H.
摘要 口服γ-Oryzanol(谷维素)90天后的大鼠,未发现体重的异常变化和脏器的异常等,因此未发现因服用γ-Oryzanol(谷维素)而会引起的副作用。


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产品名称 谷维素
发表年份 1982
杂志 日本食品工学学会杂志
标题 阿魏酸酯的抗氧化性及其与氨基化合物协同性的研究
作者 冈田忠司、中川纪代司、山口直彦
摘要 发现γ-Oryzanol(谷维素)中含有的阿魏酸酯单独对亚油酸和猪油的抗氧化性较低,但通过与甘氨酸并用可得到改善。

产品名称 谷维素
发表年份 1983
杂志 油化学
标题 谷维素的抗氧化性和药理作用
作者 冈田忠司、山口直彦
摘要 γ-Oryzanol(谷维素)具有耐热性和抗氧化活性,还具有生长促进作用、间脑功能调节作用等效果,因此有望作为食品的抗氧化物质应用和作为医药品得以应用。

产品名称 谷维素
发表年份 2017
杂志 Toxicology Reports
标题 Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats.
作者 Moon S.H., Kim D., Shimizu N., Okada T., Hitoe S., Shimoda H.
摘要 口服γ-Oryzanol(谷维素)90天后的大鼠,未发现体重的异常变化和脏器的异常等,因此未发现因服用γ-Oryzanol(谷维素)而会引起的副作用。


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产品名称 猕猴桃籽提取物
发表年份 2007
杂志 Food Science and Technology Research
标题 Suppressive effect of defatted kiwi fruit seed extract on acute inflammation and skin pigmentation.
作者 Tanaka J., Shan S.J., Kasajima N., Shimoda H.
摘要 猕猴桃种子提取物具有抑制前列腺素及NO生成、抑制酪氨酸酶活性、抑制黑色素生成、抑制色素沉着等用。


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产品名称 菊花提取物
发表年份 2017
杂志 Integrative Molecular Medicine
标题 Luteorin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia.
作者 Hirano M., Takeda S., Hitoe S., Shimoda H.
摘要 以患有轻度高尿酸血症(尿酸值5.5~7.0mg/dL)的男性为对象,经过为期4周的菊花提取物摄取后,确认尿酸值有所减少。

产品名称 菊花提取物
发表年份 2022
杂志 Functional Foods in Health and Disease
标题 Effects of luteolin-rich chrysanthemum flower extract on purine base absorption and blood uric acid in Japanese subjects
作者 Tsuyoshi Takara., Kazuo Yamamoto., Naoko Suzuki.,Shin-ichiro Yamashita., Shin-ichiro Iio., Toshihiro Kakinuma., Asami Baba., Shogo Takeda., Wakana Yamada., Masafumi Nagata., Hiroshi Shimoda.
摘要 让44名20岁以上的日本男性或女性健康者摄取12周菊花由来的木犀草素胶囊或安慰剂胶囊,评价了对较高的血清尿酸值的影响。结果显示,摄取12周菊花提取物来源的木犀草素胶囊时,高尿酸值唯一降低。


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产品名称 核桃多酚
发表年份 2008
杂志 Journal of Agricultural and Food Chemistry
标题 Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in kernel pellicles of walnut.
作者 Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T.
摘要 核桃多酚中所含的鞣花酸类可抑制因肝损伤而产生的血中GOT、GPT的释放,因此可期待其具有护肝作用。

产品名称 核桃多酚
发表年份 2009
杂志 Journal of Agricultural and Food Chemistry
标题 Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver.
作者 Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T.
摘要 研究表明,核桃多酚中所含的Tellimagrandin I可激活脂质代谢相关酶基因的表达,从而促进细胞溶液组分中的β氧化,具有降低血中和肝脏中甘油三酸酯浓度的作用。


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产品名称 黑生姜提取物
发表年份 2016
杂志 Journal of Natural Medicines
标题 Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism.
作者 Toda K., Takeda S., Hitoe S., Nakamura S. Matsuda H., Shimoda H.
摘要 黑姜提取物有望激活AMPK和提高糖、乳酸、脂质代谢相关酶基因的表达,从而改善代谢综合征和运动功能。

产品名称 黑生姜提取物
发表年份 2016
杂志 Helioyon
标题 Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism.
作者 Toda K., Hitoe S., Takeda S., Shimoda H.
摘要 黑姜提取物中所含有的多甲氧基黄酮,有望通过激活AMPK来提高肌肉耐力和运动功能。

产品名称 黑生姜提取物
发表年份 2016
杂志 Integrative Molecular Medicine
标题 Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial. I
作者 Toda K., Kohatsu M., Takeda S., Hitoe S., Shimizu N., Shimoda H.
摘要 以健康人为对象,经过为期4周的黑姜提取物摄取后,体力、握力、脚力、平衡力和持久力等运动功能以及倦怠感均得到改善。


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产品名称 紫米提取物
发表年份 2010
杂志 Biochemical Systematics and Ecology
标题 Anthocyanins from Oryza sativa L. subsp. indica.
作者 Tamura S., Yan K., Shimoda H., Murakami N.
摘要 从紫米的种皮提取物中分离出了在其他物种中未发现的二葡糖基花青素,因此有望将紫米应用于生物合成研究。

产品名称 紫米提取物
发表年份 2011
杂志 Journal of Agricultural and Food Chemistry 
标题 Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo.
作者 Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H., Hara H.
摘要 研究表明,紫米提取物中所含有的花青素和甲基花青素,可抑制由可见光引起的视细胞凋亡,从而发挥抗氧化作用。

产品名称 紫米提取物
发表年份 2012
杂志 Phytotherapy Research
标题 Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis.
作者 Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H., Hara H.
摘要 紫米提取物可抑制细胞增殖因子和细胞迁移因子的磷酸化,因而具有抑制血管新生的作用。

产品名称 紫米提取物
发表年份 2013
杂志 Life Sciences
标题 Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo.
作者 Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M, Hara H.
摘要 对于内质网应激诱发性的视网膜障碍小鼠使用紫米提取物后,抑制了BiP以及CHOP的增加作用,并由此使视细胞的死亡以及神经节细胞的肥厚得以抑制。

产品名称 紫米提取物
发表年份 2015
杂志 Journal of Rice Research
标题 Purple rice extract exhibits preventive activities on experimental diabetes models and human subjects.
作者 Shimoda H., Aitani M., Tanaka J. ,Hitoe S.
摘要 紫米提取物具有抑制α-葡萄糖苷酶、α-淀粉酶以及醛糖还原酶的作用,因此是可用于预防糖尿病及其并发症的一种重要食品原料。


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产品名称 Coprino™
发表年份 2016
杂志 Bioscience, Biotechnology and Biochemistry 
标题 A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation related DNA halogenation.
作者 Asahi T., Wu Xiaohong, Shimoda H., Harada E., Kanno T., Nakamura Y., Kato Y., Osawa T.
摘要 马鞭草提取物中所含的麦角硫因可抑制骨髓过氧化物酶活性,祛除卤素种,从而保护因UV-B而损伤的DNA,因此有望将其用作抗炎剂。


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产品名称 稻米胚芽发酵提取物
发表年份 2017
杂志 Journal of Medicinal Food
标题 Fermented rice germ extract alleviates morphological and functional damage to murine gastrocnemius muscle by inactivation of AMP-activated protein kinase.
作者 Tanaka M., Yoshino Y., Takeda S.,Toda K., Shimoda H., Tsumura K., Shimazawa M., Hara H.
摘要 米胚芽发酵提取物在模型小鼠中使肌肉量及肌力、肌纤维尺寸增加,因此可能有助于预防和治疗运动功能障碍。

SA行


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产品名称 樱花提取物
发表年份 2011
杂志 Phytotherapy Research
标题 Effect of cinnamoyl and flavonol glucosides derived from cherry blossom glowers on the production of advanced glycation end products (AGEs) and AGE-induced fibroblast apoptosis.
作者 Shimoda H., Nakamura S., Morioka M., Tanaka J., Matsuda H., Yoshikawa M.
摘要 樱花提取物中的肉桂酰和黄酮醇葡萄糖苷可抑制皮肤细胞所产生的晚期糖基化终产物(AGE),并抑制AGE所诱导的成纤维细胞凋亡,从而预防皮肤衰老。

产品名称 樱花提取物
发表年份 2018
杂志 International Journal of Biomedical Science
标题 Effect on Skin Condition by 8-week Ingestion of Standardized Cherry Blossom Flower Extract (Sakura Extract-P).
作者 Matsuyama A., Kikuchi M., Shimoda H.
摘要 以日本女性为对象,经过为期8周的樱花提取物摄取后,发现皮肤的AGE有所减少,弹性得以维持,脸上的斑点和发红有所减少。


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产品名称 紫苏籽提取物
发表年份 1998
杂志 Journal of Agricultural and Food Chemistry 
标题 Inhibitors of Arachidonate Lipoxygenase from Defatted Perilla Seed.
作者 Yamamoto H., Sakakibara J., Nagatsu A., Sekiya I.
摘要 紫苏籽中所含有的木犀草素显示出较高的脂酶抑制作用,因此有望发挥抗过敏及抗炎作用。


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产品名称 沙棘提取物
发表年份 2017
杂志 Journal of Functional Foods
标题 Suppressive effect of triterpenoids and a flavonol glycoside in seaberry extract on carbacol-induced contraction of bladder smooth muscle and TGF-α-induced contraction of collagen gel containing bladder smooth muscle cells.
作者 Shimoda H., Takeda S., Shimizu N., Hirano M. Hitoe S.
摘要 沙棘提取物可作用于膀胱平滑肌抑制膀胱收缩,因此可能预防膀胱过度活动后所引起的排尿障碍。

产品名称 沙棘提取物
发表年份 2017
杂志 Functional Foods Health and Disease.
标题 Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults.
作者 Takara T., Yamamoto K., Suzuki N., Shimoda H.
摘要 以患有轻度排尿功能障碍的日本男性和女性为对象,经过为期8周的沙棘提取物摄取后,改善了与排尿相关的“心理问题”和迫切的尿意感。由此可见,沙棘提取物可能有助于改善因膀胱过度活动而引起的排尿功能障碍。

产品名称 沙棘提取物
发表年份 2020
杂志 Japanese Pharmacology and Therapeutics
标题 Stratified analysis of a clinical trial of ursolic acid in seaberry extract on urinary anxiety in healthy Japanese subjects.
作者 Takara T., Hirano M., Yamamoto K., Suzuki N., Shimizu N., Shimoda H.
摘要 对于排除膀胱活动过度评分高的受试者,再次进行为期8周的摄取沙棘提取物人体临床试验。结果,与排尿有关的“心理问题”以及迫切的尿意感均得到改善。由此可见,沙棘提取物对于健康人的尿急有改善作用。


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产品名称 莼菜提取物
发表年份 2014
杂志 Natural Products Chemistry & Research
标题 Anti-adipogenic polyphenols of water shield suppress TNF-α-induced cell damage and enhance expression of HAS2 and HAPB2 in adiponectin treated dermal fibroblasts.
作者 Shimoda H., Nakamura S., Hitoe S., Terazawa S., Tanaka J., Matsumoto T., Matsuda H.
摘要 莼菜提取物以及作为含有成分的多酚类显示出抑制脂肪蓄积和抑制炎症的作用,并可通过激活透明质酸合成酶,来实现抑制皮肤细胞损伤的作用。

TA行


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产品名称 月见草提取物
发表年份 2002
杂志 健康与营养食品研究
标题 关于含月见草提取物的片剂食品对餐后血糖值的影响以及长期每日摄取后空腹血糖值变动及安全性的研究
作者 木场孝繁、滨田广一郎、木村弘之、阿比留康弘、曲田清彦、菊池范昭、宗行哲、高泽谦二
摘要 糖尿病边界区域对象者摄取12周含月见草提取物片剂食品后,确认了抑制餐后血糖值上升和降低空腹血糖值的安全性。由此表明,作为一种可抑制餐后血糖值上升的食品原料,对糖尿病边界区域对象者确实有效。

产品名称 月见草提取物
发表年份 2003
杂志 日本食品科学工学会诗
标题 月见草提取物对人的餐后血糖值上升的抑制作用
作者 蓝谷教夫、西村明、滨田广一郎、木场孝繁、小西洋太郎
摘要 让健康者及糖尿病患者在饭前摄取月见草提取物后,发现其具有抑制餐后血糖值上升的效果。因此可期待将其用作预防或改善糖尿病的食品原材料。

产品名称 月见草提取物
发表年份 2003
杂志 日本食品科学工学会诗
标题 月见草提取物的抑制血糖值上升作用及其相关成分
作者 蓝谷教夫、木村弘之、阿比留康弘、曾山裕子、村上裕子、张慧利、杉下朋子、小西洋太郎
摘要 文中提出,月见草提取物中所含有的原花青素可抑制α-葡萄糖苷酶,从而抑制血糖值上升。

产品名称 月见草提取物
发表年份 2014
杂志 Laboratory Animal Research
标题 In vitro and in vivo anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract.
作者 Cai J., Kim T., Jang J.Y., Kim J., Shin K., Lee S., Choi E., Kim S., Park M., Kim J.B., Kim Y.
摘要 FEMY-R7(含有褐藻糖胶提取物和月见草提取物)可抑制幽门螺杆菌的发育以及抑制尿素酶,因此有望用于预防胃炎和消化性溃疡等幽门螺杆菌感染症。


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产品名称 燕窝提取物
发表年份 2020
杂志 International Journal of Biomedical Science
标题 Keratinocyte Proliferative and Wound Healing Effects of Edible Bird’s Nest Extract on Human Skin
作者 Terazawa S., Shimoda H.
摘要 燕窝提取物具有促进皮肤细胞的增殖、创伤治愈效果、皮肤的屏障功能,因此可期待其为保持健康皮肤做出贡献。

产品名称 燕窝提取物
发表年份 2021
杂志 Antioxidants.
标题 Standardized Edible Bird's Nest Extract Prevents UVB Irradiation-Mediated Oxidative Stress and Photoaging in the Skin.
作者 Kim O., Kim D., Lee M., Park S., Yamada W., Eun S., Lee J.
摘要 燕窝提取物通过抑制由UV-B照射引起的氧化应激、保湿·弹力形成因子的活性化、抑制黑色素形成因子,因此可能对防止皮肤光老化有效。


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产品名称 藤茶提取物
发表年份 2022
杂志 Molecules
标题 The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models
作者 Jianbo Wu, Kenchi Miyasaka, Wakana Yamada, Shogo Takeda, Norihito Shimizu and Hiroshi Shimoda
摘要 文中评价了藤茶提取物及相关成分安培蛋白的抗肥胖效果(A)和护肝作用。其结果,在动物试验中表现出抑制内脏脂肪增加、提高肝脏的CPT1A活性以及抑制脂肪吸收的作用,在细胞试验中表现出促进脂肪分解的作用。而在护肝作用方面,则在酒精性模型小鼠中发现了抑制GOT、GPT的上升以及抑制脂肪肝的作用。


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产品名称 番茄籽提取物
发表年份 2021
杂志 Journal of Food Biochemistry
标题 Lycoperoside H, a steroidal alkaloid saponin in tomato seeds, ameliorates atopic dermatitis-like symptoms in IL-33 transgenic mice.
作者 Takeda S., Miyasaka K., Shimoda H.
摘要 番茄籽提取物及其含有成分番茄红素H,保湿基因的表达增加,血液及皮肤的炎症性细胞因子得以改善,由此表明其对特应性皮肤炎症状态的缓和确实有效。

产品名称 番茄籽提取物
发表年份 2021
杂志 Journal of Cosmetics, Dermatological Sciences and Applications 
标题 Tomato Seed Extract Containing Lycoperoside H Improves Skin Elasticity in Japanese Female Subjects: A Randomized, Placebo-Controlled, Double-Blind Trial.
作者 Izumi T., Yamamoto K., Suzuki N., Yamashita S., Iio S., Noguchi H., Kakinuma T., Baba A., Takeda S., Yamada W., Shimoda H.
摘要 以日本女性为对象、为期8周的番茄籽提取物摄取结果表明,番茄籽提取物可减少糖化应激,从而切实有效地维持皮肤弹性。

产品名称 番茄籽提取物
发表年份 2021
杂志 Molecules
标题 Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect
作者 Takeda S., Miyasaka K., Shrestha S., Manse Y., Morikawa T., Shimoda H.
摘要 在从番茄籽中分离出的11种化合物中,明确了红素番茄红素H是一种可通过促进角质层神经酰胺合成及类固醇样抗炎作用来实现表皮保湿的化合物。

NA行


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产品名称 生咖啡豆提取物
发表年份 2006
杂志 BMC Complementary Medicine and Therapies
标题 Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice.
作者 Shimoda H., Ski E., Aitani M.
摘要 本文中发现生咖啡豆提取物可抑制体重增加和脂肪蓄积,促进脂肪分解和燃烧。

产品名称 生咖啡豆提取物
发表年份 2009
杂志 Food Science and Technology Research
标题 Anti-obesity and hypotriglyceridemic properties of coffee bean extract in SD rats.
作者 Tanaka K., Nishizono S., Tamaru S., Kondo M., Shimoda H., Tanaka J., Okada T.
摘要 生咖啡豆提取物可抑制脂肪酸合成酶活性和促进脂肪酸分解酶活性,因此有望将其用于抑制脂肪蓄积的功能性食品原料。

产品名称 生咖啡豆提取物
发表年份 2010
杂志  Korean Journal of Nutrition
标题 The effect of green coffee bean extract supplementation on body fat reduction in over weight/obese woman.
作者 Yeon P.J., Young K.J., Pyo L.S., Ho L.J.
摘要 以超重或肥胖女性为对象,进行为期8周的生咖啡豆提取物摄取后,确认腹部内脏脂肪有所减少。通过饮食调节和运动相结合,有望取得更好的效果。

HA行


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产品名称 西番莲提取物
发表年份 2017
杂志 International Journal of Biomedical Science
标题 Passionflower extract induces high-amplitude rhythms without phase shift in the expression of several circadian clock genes in vitro and in vivo.
作者 Toda K., Hitoe S., Takeda S., Shimizu N., Shimoda H.
摘要 西番莲提取物有望通过促进时钟基因的表达来改善生活节奏紊乱。

产品名称 西番莲提取物
发表年份 2019
杂志 Functional Foods Health and Disease
标题 Passionflower extract improves diurnal quality of life in Japanese subjects with anxiety: A randomized, placebo-controlled, double-blind trial
作者 Takara T., Yamamoto K., Suzuki N., Hirano M., Shimizu N., Shimoda H.
摘要 以日本的男性和女性为对象,进行了为期12周的西番莲提取物摄取实验后,发现精神焦虑得以改善,由此认为这可能有助于提高生活质量。


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产品名称 日本款冬提取物
发表年份 2006
杂志 Journal of Agricultural and Food Chemistry
标题 Anti type I allergic property of Japanese butterbur extract and its mast cell deglanulation inhibitory ingredients.
作者 Shimoda H., Tanaka J., Yamada E., Morikawa T., Kasajima N., Yoshikawa M.
摘要 已知蜂斗菜提取物可通过对肥大细胞脱颗粒、白三烯释放及TNF-α产生的抑制作用,来实现抑制Ⅰ型过敏反应。

产品名称 日本款冬提取物
发表年份 2006
杂志 Heterocycles
标题 Medicinal food stuffs. XXXII. Novel sesquiterpene glycoside sulfate, fukinoside A, with antiallergic activity from Japanese butterbur (Petasites Japonicus)
作者 Yoshikawa M., Morikawa T., Tanaka J., Shimoda H.
摘要 从日本款冬提取物中分离出的蜂毒苷A,有效抑制了从肥大细胞中所释放出的颗粒成分——β-己糖胺酶的释放。


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产品名称 岩藻黄质
发表年份 2010
杂志 Journal of Pharmacy and Pharmacology 
标题 Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
作者 Shimoda H., Tanaka J., Shan S. J., Maoka T.
摘要 这表明,岩藻黄质可抑制前列腺素合成相关因子以及黑色素形成相关因子的表达,从而防止色素沉积。

产品名称 岩藻黄质
发表年份 2017
杂志 Functional Foods Health and Disease
标题 Seaweed fucoxanthin supplementation improves obesity parameters in mildly obese Japanese subjects.
作者 Hitoe S., Shimoda H.
摘要 以日本成年男女为对象,经过为期4周的岩藻黄质摄取后,发现体重、BMI、腹部脂肪均有所减少,由此判断有望将其用作抗肥胖食品原材料。

产品名称 岩藻黄质
发表年份 2019
杂志 Journal of Clinical Medicine
标题 Dietary fucoxanthin induces anoikis in colorectal adenocarcinoma by suppressing integrin signaling in a murine colorectal cancer model.
作者 Terasaki M, Ikuta M, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M.
摘要 文中提出岩藻黄质通过抑制整联蛋白细胞信号转导因子的表达,诱导失巢凋亡,从而抑制大肠癌的发生。

产品名称 岩藻黄质
发表年份 2019
杂志 In Vivo
标题 Salivary glycine is a significant predictor for the attenuation of polyp and tumor microenvironment formation by fucoxanthin in AOM/DSS mice.
作者 Terasaki M, Masaka S, Fukada C, Houzaki M, Endo T, Tanaka T, Maeda H, Miyashita K, Mutoh M.
摘要 对肠炎相关大肠癌模型小鼠投用岩藻黄质后发现,大肠息肉和结肠病变减少的同时,唾液中的甘氨酸量也有所减少。结果表明,可通过唾液中的甘氨酸量来预测大肠癌的肿瘤形成。

产品名称 岩藻黄质
发表年份 2019
杂志 Journal of Clinical Biochemistry and Nutrition
标题 Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine.
作者 Terasaki M, Matsumoto N, Hashimoto R, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M.
摘要 对大肠癌干细胞移植小鼠投用岩藻黄质后,发现肿瘤的形成和细胞周期蛋白D1的表达被抑制,同时肿瘤代谢物中的甘氨酸量也有所增加。结果表明,可通过肿瘤代谢产物来预测肿瘤的形成。

产品名称 岩藻黄质
发表年份 2019
杂志 Genes and Environment
标题 Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells.
作者 Tamura S, Narita T, Fujii G, Miyamoto S, Hamoya T, Kurokawa Y, Takahashi M, Miki K, Matsuzawa Y, Komiya M, Terasaki M, Yano T, Mutoh M.
摘要 通过将岩藻黄质与具有NF-κB抑制作用的食品成分组合,可提高细胞凋亡诱导,有望预防癌症。

产品名称 岩藻黄质
发表年份 2021
杂志 Nutrients
标题 Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
作者 Yoshikawa M., Hosokawa M., Miyashita K., Nishino H., Hashimoto T.
摘要 岩藻黄质不仅对脂肪的减少构成影响,还是一种能防止肌肉萎缩的有益食品原材料。

产品名称 岩藻黄质
发表年份 2021
杂志 Nutrients
标题 Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
作者 Yoshikawa M., Hosokawa M., Miyashita K., Nishino H., Hashimoto T.
摘要 マウスにフコキサンチンを摂取させることで、脂肪減少の効果に加えて、in vivoにおいて筋肉収縮を予防することが明らかとなった。

产品名称 岩藻黄质
发表年份 2023
杂志 Onco
标题 Anticancer Effects of Fucoxanthin in a PDX Model of Advanced Stage Pancreatic Cancer with Alteration of Several Multifunctional Molecules
作者 Terasaki M.,Suzuki S.,Tanaka T.,Maeda H.,Shibata M.,Miyashita K.,Kuramitsu Y.,Hamada J.,Ohta T.,Yagishita S.,Hamada A.,Sakamoto Y.,Hijioka S.,Morizane C.,Takahashi M.
摘要 フコキサンチンはすい臓がん患者の治療に効果を示す可能性が示され、がん治療薬の有力な候補となりうることが明らかとなった。


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产品名称 西兰花芽提取物
发表年份 2004
杂志 Journal of Toxicologic Pathology 
标题 Preventive effects of podered broccoli sprout on azoxymethane-induced rat colonic aberrant crypt foci.
作者 Suzuki R., KohnoH., Sugie S., Okada T., Tanaka T.
摘要 证明了摄取粉末化的西兰花芽,可显著抑制结肠癌的发病,因此西兰花芽有望用于癌症预防。

产品名称 西兰花芽提取物
发表年份 2018
杂志 Functional Foods Health and Disease
标题 Glucosinolates and isothiocyanates from broccoli seed extract suppress protein glycation and carbonylation.
作者 Hirano M., Takeda S., Hitoe S., Shimoda H.
摘要 青花菜花茎提取物及其所含成分芥子油苷,有望通过抑制糖化作用和羰基化作用来预防皮肤老化。

MA行


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产品名称 马基莓提取物
发表年份 2013
杂志 Food Chemistry
标题 Maqui berry (Aristoterlia chinensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
作者 Tanaka J., Kadekaru T., Ogawa K., Hotoe S., Shimoda H., Hara H.
摘要 研究表明,蔓越莓提取物及其主要成分飞燕草素具有抗氧化作用,可以抑制由可见光引起的视细胞凋亡。

产品名称 马基莓提取物
发表年份 2014
杂志 Journal of Functional Foods
标题 Delphinidin 3,5-O-digulucoside, a constituent of the maquiberry (Aristotelia chilensis) anthocyanin, restores teat secretion in a rat dry eye model.
作者 Nakamura S., Tanaka J., Imada T., Shimoda H., Tsubota K.
摘要 蔓越莓提取物及其主要成分飞燕草素有望促进早期发现损伤角膜、泪腺房中的细胞密度减少以及泪液分泌因子的表达,从而预防干眼。

产品名称 马基莓提取物
发表年份 2014
杂志 Panminerva Medica
标题 MaquiBrightTM standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial.
作者 Hitoe S., Tanka J., Shimoda H.
摘要 以有干眼症倾向的受试者为对象,经过为期2个月的MaquiBright摄取后;观察到了显著的泪液量增加以及干眼症QOL问卷得分减少。由此可认为,MaquiBright946对于改善干眼症切实有效。

产品名称 马基莓提取物
发表年份 2018
杂志 Journal of Traditional and Complementary Medicine 
标题 Effects of MaquiBright on imploving eye dryness and fatigue in humans: A radomized double-blind, placebo-controlled trial.
作者 Yamashita S, Suzuki N., Yamamoto K., Iio S., Yamada T.
摘要 以健康的日本男女为对象,摄取了1个月的MaquiBright9000;,泪液量的增加以及“眼疲劳”和“肩酸”得到了改善。由此可期待Maquibright911确实可作为一种改善眼疲劳的食品原材料。

产品名称 马基莓提取物
发表年份 2020
杂志 Journal of Cosmetics Dermatological Sciences and Applications
标题 Ameliorating Effects of Delphinol®, Anthocyanin Standardized Maqui Berry Extract, on Skin Brightness and Redness in Japanese Females: A Randomized Double-Blind Placebo-Controlled Pilot Study.
作者 Shimizu N., Yamada W., Miyasaka K., Shimoda, H.
摘要 以健康的日本女性为对象,经过为期8周的Delphinol的摄取后,确认了因冬季的干燥和炎症等而引发的皮肤发红减少以及骨胶原量有增加的倾向。


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产品名称 紫茶提取物
发表年份 2015
杂志 International Journal of Biomedical Science
标题 Purple tea and its extract suppress diet-induced fat accumulation in mice and human subjects by inhibiting fat absorption and enhancing hepatic carnitine palmitoyltransferase expression.
作者 Shimoda H., Hitoe S., Nakamura S., Matsuda H.
摘要 紫茶提取物可能通过抑制脂肪吸收和激活脂质代谢来抑制因饮食而引起的体重增加。

产品名称 紫茶提取物
发表年份 2020
杂志 Journal of Exercise and Nutrition
标题 Effects of Purple Tea on Muscle Hyperemia and Oxygenation, Serum Markers of Nitric Oxide Production and Muscle Damage, and Exercise Performance.
作者 Kyle Cesareo, Tim Ziegenfuss, Betsy Raub, Jennifer Sandrock, Hector Lopez
摘要 以健康男性为对象,经过为期8天的紫茶提取物摄取后,发现下半身的肌肉耐力切实得以改善,肌肉损伤指标也有所降低。由此提出,紫茶提取物可能有助于促进运动疲劳的恢复以及提高运动功能。

YA行


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RA行


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WA行


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